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- After a penetrating lesion within the central nervous system, astrocytes enlarge, divide, and take part in creating an environment that adversely impacts neuronal regeneration.
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- Hoffman S, Edelman GM. The mechanism of binding of neural cell adhesion molecules.
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After a penetrating lesion within the central nervous system, astrocytes enlarge, divide, and participate in creating an surroundings that adversely affects neuronal regeneration. We have recently proven that the neural cell adhesion molecule (N-CAM) partially inhibits the division of early postnatal rat astrocytes in vitro. Animals have been lesioned in the cerebral cortex, hippocampus, or striatum with a Hamilton syringe and needle at defined stereotaxic positions. On one side, the lesions have been concomitantly infused with N-CAM or with one of many N-CAM-related molecules. As a management, a peptide of the identical composition as the N-CAM decapeptide but of random sequence was infused on the contralateral aspect of the brain. The inhibition was best in the cortical lesion websites (approximately 50%) and was less pronounced in the hippocampus (approximately 25%) and striatum (approximately 20%). Two weeks after the lesion, the cerebral cortical sites infused with N-CAM continued to exhibit a significantly smaller population of dividing astrocytes than the sites on the other facet.
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Del Rio JA, Soriano E. Immunocytochemical detection of 5′-bromodeoxyuridine incorporation within the central nervous system of the mouse. Giulian D, Chen J, Ingeman JE, George JK, Noponen M. The function of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian mind. Smith GM, Rutishauser U, Silver J, Miller RH. Maturation of astrocytes in vitro alters the extent and molecular foundation of neurite outgrowth. Full text is out there as a scanned copy of the original print model. Get a printable copy of the whole article (1.6M), or click on on a web page image beneath to browse page by web page. Links to PubMed are also available for Selected References. Immunohistological localization of the adhesion molecules L1, N-CAM, and MAG in the developing and adult optic nerve of mice.
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I want help in finishing these projects, currently. This is straightforward level and if you’re skilled in c++, could be done in quickly. Janeczko K. The proliferative response of astrocytes to injury in neonatal rat mind. A combined immunocytochemical and autoradiographic research.